Monika Krasowska, M.B.A. Djamgoz, I. Ozerlat, M. Mycielska, Z.J. Grzywna
A mathematical description of wound healing assay
Cell migration is a complex phenomenon that requires the coordination of numerous
cellular processes. Investigation of cell migration is of common as well as for
clinicians. The wound healing assay is simple, inexpensive, and one of
the earliest developer methods to study directional cell migration in vitro.
The basic steps involve creating a "wound" in a cell monolayer,
capturing the images at the beginning and at regular intervals during cell
migration to close the wound. The above process is modeled in this work by
symmetric sorption and described by the hyperbolic diffusion equation
(correlated random walk process). We have compared this model with experimental
data showing quite a good agreement.